13027-33-3
13027-33-3 structure
- Name: 3β,5α-Dihydroxycholestan-6-one
- Chemical Name: 5alpha-cholestan-3beta,5alpha-diol-6-one
- CAS Number: 13027-33-3
- Molecular Formula: C27H46O3
- Molecular Weight: 418.652
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-02-13 08:00:00
- Modify Date: 2025-08-27 00:44:38
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5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].
| Name | 5alpha-cholestan-3beta,5alpha-diol-6-one |
|---|---|
| Synonyms |
CHOLESTANE-6-OXO-3,5-DIOL
Cholestan-6-one, 3,5-dihydroxy-, (3β,5α)- (3β,5α)-3,5-Dihydroxycholestan-6-one CHOLESTANE-6-OXO-3BETA,5ALPHA-DIOL 5ALPHA-HYDROXY-6-KETO CHOLESTEROL YS-64 yakkasterone 3β,5α-Dihydroxycholestan-6-one |
| Description | 5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 5α-Hydroxy-6-keto cholesterol (0.01, 0.1, 1, 10 μM) is cytotoxic to cultured 16-HBE cells[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 528.9±45.0 °C at 760 mmHg |
| Molecular Formula | C27H46O3 |
| Molecular Weight | 418.652 |
| Flash Point | 287.7±25.2 °C |
| Exact Mass | 418.344696 |
| PSA | 57.53000 |
| LogP | 7.00 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.531 |