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Demethoxypiplartine

Names

[ CAS No. ]:
130263-10-4

[ Name ]:
Demethoxypiplartine

[Synonym ]:
2(1H)-Pyridinone, 1-[(2E)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]-5,6-dihydro-
Demethoxypiplartine
1-[(2E)-3-(3,4-Dimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone

Biological Activity

[Description]:

Demethoxypiplartine is an amide alkaloids which can be isolated from Piper flaviflorum and Piper sarmentosum. Demethoxypiplartine has antifungal activity against Cryptococcus neoformans with the IC50 of 18.1 μg/mL[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Shi YN, et al. Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum. Planta Med. 2017 Jan;83(1-02):143-150.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
449.6±45.0 °C at 760 mmHg

[ Melting Point ]:
116-117℃ (methanol )

[ Molecular Formula ]:
C16H17NO4

[ Molecular Weight ]:
287.31

[ Flash Point ]:
225.7±28.7 °C

[ Exact Mass ]:
287.115753

[ PSA ]:
55.84000

[ LogP ]:
2.58

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.593

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds