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Argipressin Acetate

Names

[ CAS No. ]:
129979-57-3

[ Name ]:
Argipressin Acetate

[Synonym ]:
[ARG8]VASOPRESSIN TFA
ARGIPRESSIN ACETATE
[Arg8]Vasopressin acetate
ArgipressinAcetate
Argipressin Acetate

Biological Activity

[Description]:

Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
Research Areas >> Neurological Disease

[In Vitro]

Argipressin (Arg8-vasopressin) (acetate) 在啮齿动物和人类 β 细胞中诱导增殖并阻止细胞因子诱导的细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Increased proliferation of rodent and human beta-cells. Apoptosis Analysis[1] Cell Line: clonal BRIN BD11 and 1.1B4 cells Concentration: 10-6 M Incubation Time: 2 h Result: Protected against cytokine-induced beta-cell apoptosis.

[In Vivo]

Argipressin (diacetate) (AVP (diacetate)) (25 nmol/kg bw; 腹腔内注射; 一次) 显着降低小鼠的总体 AUC 葡萄糖值,但不增加小鼠的胰岛素水平[1]。 Animal Model: NIH Swiss mice (adult; male; 12-14weeks)[1] Dosage: 25 nmol/kg bw Administration: AVP (25 nmol/kg bw; intraperitoneal injection; once) Result: Reduced (P<0.001) overall AUC glucose values,but not increased insulin levels in mice.

[References]

[1]. Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie.  

[2]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.  

[3]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.  

[4]. Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257.  

Chemical & Physical Properties

[ Molecular Formula ]:
C48H69N15O14S2

[ Molecular Weight ]:
1144.28000

[ Exact Mass ]:
1143.46000

[ PSA ]:
549.33000

[ LogP ]:
1.25190

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20

[ Safety Phrases ]:
36

[ WGK Germany ]:
3


Related Compounds