AKT-IN-2

Names

[ CAS No. ]:
1295514-91-8

[ Name ]:
AKT-IN-2

Biological Activity

[Description]:

AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt1:5 nM (IC50)

P70S6K:399 nM (IC50)

PKA:84 nM (IC50)

PKCβ2:3.98 μM (IC50)

RSK1:568 nM (IC50)

pGSK3β:92 nM (IC50)


[In Vitro]

AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β with IC50s of 0.399, 0.084, 3.98, 0.568, and 0.092 μM, respectively[1].

[References]

[1]. Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H34F3N7O

[ Molecular Weight ]:
505.58

Related Compounds