RB-6145

Names

[ Name ]:
RB-6145

[Synonym ]:
1H-IMIDAZOLE-1-ETHANOL,A-[[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-,HYDROBROMIDE (1:1)
2-Chloro-N-(2,2-dichloro-1-cyano-vinyl)-acetamide
Acetamide,2-chloro-N-(2,2-dichloro-1-cyanoethenyl)
1-(2-nitro-1-imidazolyl)-3-(2-bromoethylamino)-2-propanol hydrobromide
3,3-dichloro-2-(2-chloro-acetylamino)-acrylonitrile

Biological Activity

[Description]:

RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21(2):387-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₄Br₂N₄O₃

[ Molecular Weight ]:
374.03000

[ Exact Mass ]:
371.94300

[ PSA ]:
95.90000

[ LogP ]:
2.00890