129448-97-1

129448-97-1 structure

Name: RB-6145
Chemical Name: 1-[(2-Bromoethyl)amino]-3-(2-nitro-1H-imidazol-1-yl)-2-propanol h ydrobromide (1:1)
CAS Number: 129448-97-1
Molecular Formula: C₈H₁₄Br₂N₄O₃
Molecular Weight: 374.03000
Catalog: Research Areas Cancer
Create Date: 2017-08-22 19:43:52
Modify Date: 2024-01-12 20:27:38
RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].

Name	1-[(2-Bromoethyl)amino]-3-(2-nitro-1H-imidazol-1-yl)-2-propanol h ydrobromide (1:1)
Synonyms	1H-IMIDAZOLE-1-ETHANOL,A-[[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-,HYDROBROMIDE (1:1) 2-Chloro-N-(2,2-dichloro-1-cyano-vinyl)-acetamide Acetamide,2-chloro-N-(2,2-dichloro-1-cyanoethenyl) 1-(2-nitro-1-imidazolyl)-3-(2-bromoethylamino)-2-propanol hydrobromide 3,3-dichloro-2-(2-chloro-acetylamino)-acrylonitrile

Description	RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21(2):387-95.