LY2881835

Names

[ Name ]:
LY2881835

[Synonym ]:
(3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid
Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4-(spiro[1H-indene-1,4'-piperidin]-1'-ylmethyl)phenyl]methoxy]-, (βS)-

Biological Activity

[Description]:

A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.

[References]

References 1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916. View Related Products by Target Free Fatty Acid Receptor (FFAR)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
676.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₃H₃₃NO₃

[ Molecular Weight ]:
491.620

[ Flash Point ]:
363.0±31.5 °C

[ Exact Mass ]:
491.246033

[ LogP ]:
6.08

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds

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