1292290-38-0
1292290-38-0 structure
- Name: LY2881835
- Chemical Name: (3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid
- CAS Number: 1292290-38-0
- Molecular Formula: C33H33NO3
- Molecular Weight: 491.620
- Catalog: Signaling Pathways GPCR/G Protein GPR40
- Create Date: 2020-01-11 13:07:49
- Modify Date: 2023-01-17 10:32:56
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A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.
| Name | (3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid |
|---|---|
| Synonyms |
(3S)-3-(4-{[4-(1'H-Spiro[indene-1,4'-piperidin]-1'-ylmethyl)benzyl]oxy}phenyl)-4-hexynoic acid
Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4-(spiro[1H-indene-1,4'-piperidin]-1'-ylmethyl)phenyl]methoxy]-, (βS)- |
| Description | A potent, selective, orally available GPR40 agonist with EC50 of 8 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo. |
|---|---|
| References | References 1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916. View Related Products by Target Free Fatty Acid Receptor (FFAR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.6±55.0 °C at 760 mmHg |
| Molecular Formula | C33H33NO3 |
| Molecular Weight | 491.620 |
| Flash Point | 363.0±31.5 °C |
| Exact Mass | 491.246033 |
| LogP | 6.08 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.658 |