Sauristolactam (Saurolactam)

Names

[ Name ]:
Sauristolactam (Saurolactam)

Biological Activity

[Description]:

Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70(5):391-6.

[2]. Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72(3):719-26.

Chemical & Physical Properties

[ Density]:
1.403g/cm3

[ Boiling Point ]:
579ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₃NO₃

[ Molecular Weight ]:
279.29

[ Flash Point ]:
304ºC

[ Exact Mass ]:
279.09000

[ PSA ]:
51.46000

[ LogP ]:
2.99690

[ Vapour Pressure ]:
5.26E-14mmHg at 25°C

[ Index of Refraction ]:
1.759

Related Compounds

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