Arbutamine

Names

[ Name ]:
Arbutamine

[Synonym ]:
4-[(1R)-1-Hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]-1,2-b enzenediol

Biological Activity

[Description]:

Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β-adrenoceptor[1]

[In Vivo]

Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).

[References]

[1]. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70.

[2]. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.

Chemical & Physical Properties

[ Density]:
1.262g/cm3

[ Boiling Point ]:
578.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₃NO₄

[ Molecular Weight ]:
317.38000

[ Flash Point ]:
195.1ºC

[ Exact Mass ]:
317.16300

[ PSA ]:
92.95000

[ LogP ]:
2.84020

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.