Tolytoxin

Names

[ Name ]:
Tolytoxin

Biological Activity

[Description]:

Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[In Vivo]

Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg.

[References]

[1]. G M Patterson, et al. Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria. Arch Microbiol. 1992;157(5):406-10.

[2]. Aysegul Dilsizoglu Senol, et al. Effect of tolytoxin on tunneling nanotube formation and function. Sci Rep. 2019 Apr 5;9(1):5741.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₆H₇₅NO₁₃

[ Molecular Weight ]:
850.09

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.