(R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinamide

Names

[ CAS No. ]:
1276013-77-4

[ Name ]:
(R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinamide

[Synonym ]:
(R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-trimethyl-propyl)-nicotinamide

Biological Activity

[Description]:

VU0404251 is a highly potent positive allosteric modulator of mGlu for the study of psychosis[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[References]

[1]. Manka JT, et al. Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6481-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃FN₂O₂

[ Molecular Weight ]:
330.39700

[ Exact Mass ]:
330.17400

[ PSA ]:
51.22000

[ LogP ]:
4.35500

Related Compounds

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