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Antibacterial agent 125

Names

[ CAS No. ]:
1274611-43-6

[ Name ]:
Antibacterial agent 125

Biological Activity

[Description]:

Antibacterial agent 125 is an antibacterial agent. Antibacterial agent 125 has a potent antimicrobial activity against clinically relevant Gram-positive pathogens with MIC50 values range from 0.25 - 8 μM. Antibacterial agent 125 can be used for the research of antimicrobial resistance[1].

[Related Catalog]:

Research Areas >> Infection
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC50: 0.25 - 8 μM (Gram-positive pathogens)[1]


[In Vitro]

Antibacterial agent 125 对临床相关的革兰氏阳性病原体具有活性，MIC50 值为 0.25-8 μM[1]。 Antibacterial agent 125 对耐甲氧西林 Staphylococcus aureus strain 菌株具有抑制活性，且在人体细胞中未表现出细胞毒性[1]。 Antibacterial agent 125 具有高代谢稳定性和优异的安全性[1]。 Antibacterial agent 125 传代 10 次后不产生耐药性，具有中度抑制生物膜形成的能力[1]。

[References]

[1]. Francesca Brunelli, et al. Isocyanides in med chem: A scaffold hopping approach for the identification of novel 4-isocyanophenylamides as potent antibacterial agents against methicillin-resistant Staphylococcusaureus. Eur J Med Chem. 2022 Nov 26;246:114950.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H11ClN2O

[ Molecular Weight ]:
270.71

Related Compounds