Sar- [D-Phe8] -des-Arg9-Bradykinin

Names

[ Name ]:
Sar- [D-Phe8] -des-Arg9-Bradykinin

[Synonym ]:
[Sar,D-Phe8,des-Arg9]bradykinin
D-Phenylalanine, N-methylglycyl-N5-(diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-
N-Methylglycyl-N5-(diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-D-phenylalanine

Biological Activity

[Description]:

Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings[1].

[Related Catalog]:

Research Areas >> Endocrinology

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

[References]

[1]. Levesque L, et al. Regulation of kinin-induced contraction and DNA synthesis by inflammatory cytokines in the smooth muscle of the rabbit aorta. Br J Pharmacol. 1995 Sep;116(1):1673-9.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₄₇H₆₆N₁₂O₁₁

[ Molecular Weight ]:
975.10

[ Exact Mass ]:
974.497375

[ LogP ]:
0.44

[ Index of Refraction ]:
1.677

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.