Gancaonin I

Names

[ Name ]:
Gancaonin I

[Synonym ]:
4-[4,6-Dimethoxy-5-(3-methyl-2-buten-1-yl)-1-benzofuran-2-yl]-1,3-benzenediol
4-[4,6-dimethoxy-5-(3-methylbut-2-en-1-yl)-1-benzofuran-2-yl]benzene-1,3-diol
1,3-Benzenediol, 4-[4,6-dimethoxy-5-(3-methyl-2-buten-1-yl)-2-benzofuranyl]-
4-[4,6-Dimethoxy-5-(3-methyl-but-2-enyl)-benzofuran-2-yl]-benzene-1,3-diol
Gancaonin I
4-(4,6-Dimethoxy-5-(3-methyl-but-2-enyl)-benzofuran-2-yl)-benzene-1,3-diol
4-[4,6-dimethoxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol

Biological Activity

[Description]:

Gancaonin I, an Isoflavone, exhibits moderate inhibition on human carboxylesterase 2 (hCES2A) with IC50 of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Yun-Qing Song, et al. Discovery of hCES2A inhibitors from Glycyrrhiza inflate via combination of docking-based virtual screening and fluorescence-based inhibition assays. Food Funct. 2021 Jan 7;12(1):162-176.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
534.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₅

[ Molecular Weight ]:
354.396

[ Flash Point ]:
276.9±28.7 °C

[ Exact Mass ]:
354.146729

[ PSA ]:
72.06000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.611

Safety Information

[ Hazard Codes ]:
Xi

Gancaonin I

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds