Mal-amido-PEG4-acid

Names

[ CAS No. ]:
1263045-16-4

[ Name ]:
Mal-amido-PEG4-acid

[Synonym ]:
19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Mal-Amido-PEG4-acid
MAL-PEG4-CH2CH2COOH

Biological Activity

[Description]:

Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₈N₂O₉

[ Molecular Weight ]:
416.42300

[ Exact Mass ]:
416.17900

[ PSA ]:
140.70000

[ Storage condition ]:
2-8°C

Mal-amido-PEG4-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds