Ganaplacide

Names

[ Name ]:
Ganaplacide

[Synonym ]:
2-Amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-8,8-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]ethanone
85VMN9JU7A
Ethanone, 2-amino-1-[2-(4-fluorophenyl)-3-[(4-fluorophenyl)amino]-5,6-dihydro-8,8-dimethylimidazo[1,2-a]pyrazin-7(8H)-yl]-
KAF156
MFCD28502124

Biological Activity

[Description]:

Ganaplacide (KAF156) is a first-in-class,orally active imidazolopiperazine antimalarial agent.Ganaplacide is active against a broad range of Plasmodiumspecies, including drug-resistant parasites. Ganaplacide is parasiticidalagainst both asexual and sexual blood stages as well as the liver stages of theparasite[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Leong FJ, et al. A first-in-humanrandomized, double-blind, placebo-controlled, single- and multiple-ascendingoral dose study of novel Imidazolopiperazine KAF156 to assess its safety,tolerability, and pharmacokinetics in healthy adult volunteers. AntimicrobAgents Chemother. 2014;58(11):6437-6443.

[2]. Kuhen KL, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother. 2014;58(9):5060-5067.

[3]. Leong FJ, et al. A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers. Antimicrob Agents Chemother. 2014;58(11):6437-6443.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
635.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃F₂N₅O

[ Molecular Weight ]:
411.45

[ Flash Point ]:
337.8±31.5 °C

[ Exact Mass ]:
411.187073

[ LogP ]:
4.20

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.639

Related Compounds

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