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Boc-NH-PEG1-CH2CH2COOH

Names

[ CAS No. ]:
1260092-44-1

[ Name ]:
Boc-NH-PEG1-CH2CH2COOH

[Synonym ]:
Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-
3-[2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]propanoic acid
MFCD22574796
t-Boc-N-amido-PEG1-acid
t-boc-N-amido-PEG1-propionic acid

Biological Activity

[Description]:

Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.

[2]. Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
385.0±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H19NO5

[ Molecular Weight ]:
233.262

[ Flash Point ]:
186.7±23.7 °C

[ Exact Mass ]:
233.126328

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

Related Compounds