Synstatin (92-119)

Names

[ CAS No. ]:
1259384-47-8

[ Name ]:
Synstatin (92-119)

Biological Activity

[Description]:

Synstatin (92-119) is an anti-tumor agent that inhibits angiogenesis and cancer cell invasion. Synstatin (92-119) down-regulates integrin α?β3 and reduces the activation of angiogenic growth factors VEGF and FGF-2[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cytoskeleton >> Integrin

[References]

[1]. Metwaly HA, et al. Inhibition of the signaling pathway of syndecan-1 by synstatin: A promising anti-integrin inhibitor of angiogenesis and proliferation in HCC in rats. Arch Biochem Biophys. 2018 Aug 15;652:50-58.  

[2]. Rapraeger AC. Synstatin: a selective inhibitor of the syndecan-1-coupled IGF1R-αvβ3 integrin complex in tumorigenesis and angiogenesis. FEBS J. 2013 May;280(10):2207-15.  

Chemical & Physical Properties

[ Molecular Formula ]:
C133H207N35O46

[ Molecular Weight ]:
3032.27

Related Compounds