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Sarpogrelate

Names

[ CAS No. ]:
125926-17-2

[ Name ]:
Sarpogrelate

[Synonym ]:
UNII-19P708E787
Sarpogrelate Hydrochloride
Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester
4-{[1-(Dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}-2-propanyl]oxy}-4-oxobutanoic acid
Sarpogrelate

Biological Activity

[Description]:

Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate (MCI-9042) increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2 Receptor


[In Vitro]

Sarpogrelate (MCI-9042) induces a significant decrease in plasma serotonin (5-HT) concentration and after 2 weeks increases significantly the concentration of whole blood 5-HT. Sarpogrelate (MCI-9042) increases significantly plasma tryptophan concentration after 2 and 4 weeks, and no changes in plasma 5-HIAA concentration. Sarpogrelate (MCI-9042) also has a tendency to increase the concentration of whole blood tryptophan concentration, did not show significant changes in platelet aggregation induced by ADP and collagen. Sarpogrelate (MCI-9042) increases significantly platelet aggregation induced by serotonin after 2 weeks[1].

[References]

[1]. A Rydzewski, et al. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thromb Res. 1996 Dec 15;84(6):445-52.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
585.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H31NO6

[ Molecular Weight ]:
429.506

[ Flash Point ]:
308.1±30.1 °C

[ Exact Mass ]:
429.215149

[ PSA ]:
85.30000

[ LogP ]:
3.68

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.551

Related Compounds