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Apremilast-d5

Names

[ CAS No. ]:
1258597-47-5

[ Name ]:
Apremilast-d5

[Synonym ]:
Apremilast D5
Apremilast-d5

Biological Activity

[Description]:

Apremilast D5 (CC-10004 D5) is a deuterium labeled Apremilast. Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Target]

PDE4

TNF-α


[References]

[1]. Perez-Aso M, et al. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015 Sep 15;17:249.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H19D5N2O7S

[ Molecular Weight ]:
465.53100

[ Exact Mass ]:
465.16200

[ PSA ]:
127.46000

[ LogP ]:
3.52590

Related Compounds