Fibronectin Adhesion-Promoting Peptide trifluoroacetate salt

Heparin Binding Peptide is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Cardiovascular Disease

GRGDS and Heparin Binding Peptide (WQPPRARI peptide) micropatterns increase the endothelialisation of prosthetic materials in vitro. WQPPRARI peptide also enhances haptotactic cell migration. The anti-apoptotic effects of fibronectin require the presence of the WQPPRARI sequence, which may be due to synergistic survival signals mediated by this sequence and by the RGD motif[1]. RDGS and WQPPRARI peptides promote cell adhesion through different activation pathways that induce different forms of adhesion which can be highlighted through the analysis of focal and fibrillar contacts[2].

[1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90.

[2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59.

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline