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Lyciumin A

Names

[ CAS No. ]:
125708-06-7

[ Name ]:
Lyciumin A

Biological Activity

[Description]:

Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Signaling Pathways >> Metabolic Enzyme/Protease >> Renin

[Target]

proteases[2], renin[2], angiotensin-converting enzyme[2]


[In Vitro]

Lyciumin A inhibits renin activities by 19.4% (40 μg/mL).

[References]

[1]. Kersten RD, et, al. Gene-guided discovery and engineering of branched cyclic peptides in plants. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10961-E10969.

[2]. Rubin GM, et, al. Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides. J Ind Microbiol Biotechnol. 2020 Oct;47(9-10):659-674.

Chemical & Physical Properties

[ Molecular Formula ]:
C42H51N9O12

[ Molecular Weight ]:
873.90700

[ Exact Mass ]:
873.36600

[ PSA ]:
306.70000

[ LogP ]:
0.18210

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds