prochlorperazine edisylate
Names
[ CAS No. ]:
1257-78-9
[ Name ]:
prochlorperazine edisylate
[Synonym ]:
2-CHLORO-10-[3-(4-METHYL-1-PIPERAZINYL)PROPYL]PHENOTHIAZINE 1,2-ETHANEDISULFONATE (1:1)
2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazineedisylate
2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine1,2-ethanedisulfo
PROCHLORPERAZINE ETHANE DISULFONATE
ethane-1,2-disulphonic acid,compound with 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine (1:1)
prochlorperazine edisylate usp
2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazinethanedisulfona
Chemical & Physical Properties
[ Boiling Point ]:
524.8ºC at 760 mmHg
[ Molecular Formula ]:
C22H30ClN3O6S3
[ Molecular Weight ]:
564.13800
[ Flash Point ]:
271.2ºC
[ Exact Mass ]:
563.09900
[ PSA ]:
160.52000
[ LogP ]:
5.44460
[ Vapour Pressure ]:
4.15E-11mmHg at 25°C
[ Storage condition ]:
2-8℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO2975000
- CHEMICAL NAME :
- Phenothiazine, 2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-, ethanedisulfonate
- CAS REGISTRY NUMBER :
- 1257-78-9
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H24-Cl-N3-S.C2-H6-O6-S2
- MOLECULAR WEIGHT :
- 564.18
- WISWESSER LINE NOTATION :
- T C666 BN ISJ EG B3- AT6N DNTJ D1 &WSQ2SWQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 177 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 350 mg/kg
- SEX/DURATION :
- female 7-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 205,1220,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3225 No. of Facilities: 70 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4939 (estimated) No. of Female Employees: 4444 (estimated)
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22
[ RTECS ]:
SO2975000