7-oxo Staurosporine

Names

[ Name ]:
7-oxo Staurosporine

Biological Activity

[Description]:

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> TGF-beta/Smad >> PKC

[In Vitro]

7-Oxostaurosporine (50 nM, 24 h)可以导致 CHO 细胞中质膜鞘磷脂增加，但不会改变神经酰胺含量[1]。

[In Vivo]

7-Oxostaurosporin（6 mg/kg，每天一次，静脉注射）显着降低肿瘤生长，肿瘤生长抑制（TGI）为 56.1%，对体重无明显影响[2]。

[References]

[1]. Masashi Maekawa, et al. Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine. Sci Rep. 2016 Nov 2;6:35762.

[2]. Feng Song, et al. The anticancer activity of carbazole alkaloids. Arch Pharm (Weinheim). 2022 Jan;355(1):e2100277.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₄N₄O₄

[ Molecular Weight ]:
480.51500

[ Exact Mass ]:
480.18000

[ PSA ]:
90.01000

[ LogP ]:
4.39550

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport