oxyphencyclimine

Names

[ CAS No. ]:
125-53-1

[ Name ]:
oxyphencyclimine

[Synonym ]:
cyclohexyl-hydroxy-phenyl-acetic acid-(1-methyl-1,4,5,6-tetrahydro-pyrimidin-2-ylmethyl ester)
1-methyl-5,6-dihydro-4H-pyrimidin-2-ylmethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Antulcus
Daricol
Naridan
Oxyphencycliminum
Oxiphencycliminum
Oxyphencycliminum [INN-Latin]
Cyclohexyl-hydroxy-phenyl-essigsaeure-(1-methyl-1,4,5,6-tetrahydro-pyrimidin-2-ylmethylester)
Oxifencicliminum
Caridan
Manir

Biological Activity

[Description]:

Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> mAChR

[In Vivo]

Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model[1]. Animal Model: Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model)[1]. Dosage: 10 mg/kg Administration: Oral administration; single. Result: Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively. Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively. Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.

Chemical & Physical Properties

[ Density]:
1.188 g/cm3

[ Boiling Point ]:
528.165ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈N₂O₃

[ Molecular Weight ]:
344.44800

[ Flash Point ]:
273.225ºC

[ Exact Mass ]:
344.21000

[ PSA ]:
62.13000

[ LogP ]:
2.10520

Related Compounds

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