<Suppliers Price>

Aza197

Names

[ CAS No. ]:
1249398-09-1

[ Name ]:
Aza197

Biological Activity

[Description]:

AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cytoskeleton >> PAK
Signaling Pathways >> GPCR/G Protein >> Ras
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Zins K, et al. Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. J Transl Med. 2013 Nov 27;11:295.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H36N6

[ Molecular Weight ]:
408.58

Related Compounds