Big Endothelin-1 (22-38), human

Names

[ Name ]:
Big Endothelin-1 (22-38), human

Biological Activity

[Description]:

Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[In Vitro]

Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs[2].

[In Vivo]

Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly[3]. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3].

[References]

[1]. Hemsén A, et al. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21). Regul Pept. 1995 Feb 14;55(3):287-97.

[2]. D'Orléans-Juste P, et al. Human big endothelin releases prostacyclin in vivo and in vitro through a phosphoramidon-sensitive conversion to endothelin-1. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S251-5.

[3]. Huneidi AH, et al. Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. J Cardiovasc Pharmacol. 1991;17 Suppl 7:S492-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₀H₁₂₅N₂₃O₂₅

[ Molecular Weight ]:
1808.99000

[ Exact Mass ]:
1807.92000

[ PSA ]:
754.44000

Related Compounds

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