- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Big Endothelin-1 Fragment (22-38) (human)
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
124932-61-2
124932-61-2 structure
- Name: Big Endothelin-1 (22-38), human
- Chemical Name: Big Endothelin-1: 22-38, human
- CAS Number: 124932-61-2
- Molecular Formula: C80H125N23O25
- Molecular Weight: 1808.99000
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-12-10 18:51:45
- Modify Date: 2024-01-07 16:42:33
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Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1].
| Name | Big Endothelin-1: 22-38, human |
|---|
| Description | Big Endothelin-1 (22-38), human is derived from human, is the 22-38 fragment of Big Endothelin-1 (ET-1) (1-38). Big ET-1 (1-38) is a propeptide of ET-1, which has potent and long-lasting vasoconstrictor effects, equips a specific enzymatic cleavage of the 38 amino acid chain to form ET-1 (1-21) and the C-terminal fragment Big ET-1 (22-38)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Big Endothelin-1 (22-38), human (0.1 μM; 30 min) induces the release of prostacyclin (PGI2) from rabbit, guinea pig, and rat lungs[2]. |
| In Vivo | Big Endothelin-1 (22-38), human (3 nM/kg; intra-arterial injection; single dose) produces a significant rise in left ventricular systolic pressure (LVSP) in anesthetized rabbits, and is enhanced by cyclooxygenase inhibitor Indomethacin (HY-14397) (5 mg/kg i.v.) significantly[3]. Big Endothelin-1 (22-38), human (3 nM/kg; intravascular method; single dose), has no antiaggregatory properties for platelet induced by ADP in rabbits[3]. |
| References |
| Molecular Formula | C80H125N23O25 |
|---|---|
| Molecular Weight | 1808.99000 |
| Exact Mass | 1807.92000 |
| PSA | 754.44000 |