6-aminocarbovir

[ Melting Point ]:
180-182°C

[ Molecular Formula ]:
C₁₁H₁₄N₆O

[ Molecular Weight ]:
246.26800

[ Exact Mass ]:
246.12300

[ PSA ]:
115.87000

[ LogP ]:
1.26260

[ Vapour Pressure ]:
1.21E-16mmHg at 25°C

[ Storage condition ]:
-20?C Freezer

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
41-43

[ Safety Phrases ]:
26-36/37-39

[ RIDADR ]:
NONH for all modes of transport

Click to get detail synthetic route

Precursor

DownStream

Comparative brain exposure to (-)-carbovir after (-)-carbovir or (-)-6-aminocarbovir intravenous infusion in rats.

Pharm. Res. 12(6) , 911-5, (1995)

Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve the CNS exposure to (-)-carbovir ((-)-CBV).Activation of (-)-6AC in vitro was assessed by incubations of rat brain tissue homogenates. ...

Pharmacokinetic evaluation of (-)-6-aminocarbovir as a prodrug for (-)-carbovir in rats.

Drug Metab. Dispos. 20(1) , 47-51, (1992)

The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CB...

First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme.

Drug Metab. Dispos. 27(1) , 113-21, (1999)

Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine...

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