Curcumin D6

Names

[ CAS No. ]:
1246833-26-0

[ Name ]:
Curcumin D6

[Synonym ]:
Halad-d6
Haidr-d6
Diferuloylmethane-d6
Curcumine-d6
Curcuma-d6
Ukon-d6
Haldar-d6
Curcumin-d6
C Yellow 15-d6

Biological Activity

[Description]:

Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Infection
Signaling Pathways >> Apoptosis >> Ferroptosis
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Autophagy >> Mitophagy
Research Areas >> Metabolic Disease
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Gao S, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004.

[2]. Nasiri M, et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53.

[3]. Jiang H, et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4.

[4]. Guo H, et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4.

[5]. Zhu X, et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H14D6O6

[ Molecular Weight ]:
374.41700

[ Exact Mass ]:
374.16400

[ PSA ]:
93.06000

[ LogP ]:
3.36990

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds