Bis-PEG8-acid

Names

[ Name ]:
Bis-PEG8-acid

Biological Activity

[Description]:

Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Cleavable

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Gregory Slobodkin, et al. Polyamine derivatives. WO2010108108A2

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₈O₁₂

[ Molecular Weight ]:
470.51

[ Storage condition ]:
2-8°C

Related Compounds

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