GSK 2250665A

Names

[ Name ]:
GSK 2250665A

[Synonym ]:
trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol
Cyclohexanol, 4-[[4-[(6-ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]-, trans-

Biological Activity

[Description]:

GSK-2250665A (Compound 13) is a selective Itk inhibitor with a pKi of 9.2.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[In Vitro]

GSK-2250665A (Compound 13) achieves a pIC50 of 7.3 in the cell assay, measuring inhibition of IFNγ production from PBMCs (Peripheral Blood Mononuclear Cells) [1].

[References]

[1]. Alder CM, et al. Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy. ACS Med Chem Lett. 2013 Aug 12;4(10):948-52.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
676.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₉N₅OS

[ Molecular Weight ]:
459.606

[ Flash Point ]:
363.0±34.3 °C

[ Exact Mass ]:
459.209290

[ LogP ]:
5.31

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.713

Related Compounds

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