1246030-96-5
1246030-96-5 structure
- Name: GSK 2250665A
- Chemical Name: trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol
- CAS Number: 1246030-96-5
- Molecular Formula: C26H29N5OS
- Molecular Weight: 459.606
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Itk
- Create Date: 2021-01-09 16:35:11
- Modify Date: 2024-01-12 12:41:34
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GSK-2250665A (Compound 13) is a selective Itk inhibitor with a pKi of 9.2.
| Name | trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol |
|---|---|
| Synonyms |
trans-4-({4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]-2-pyrimidinyl}amino)cyclohexanol
Cyclohexanol, 4-[[4-[(6-ethyl-2-benzothiazolyl)amino]-6-(phenylmethyl)-2-pyrimidinyl]amino]-, trans- |
| Description | GSK-2250665A (Compound 13) is a selective Itk inhibitor with a pKi of 9.2. |
|---|---|
| Related Catalog | |
| In Vitro | GSK-2250665A (Compound 13) achieves a pIC50 of 7.3 in the cell assay, measuring inhibition of IFNγ production from PBMCs (Peripheral Blood Mononuclear Cells) [1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.6±65.0 °C at 760 mmHg |
| Molecular Formula | C26H29N5OS |
| Molecular Weight | 459.606 |
| Flash Point | 363.0±34.3 °C |
| Exact Mass | 459.209290 |
| LogP | 5.31 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.713 |