QM295

Names

[ Name ]:
QM295

Biological Activity

[Description]:

QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[In Vitro]

QM295（25 μM，50 μM）在动力学测定中抑制 AUR 荧光的发展，IC50 值为 1.9 μM[1]。

[In Vivo]

QM295 (50 μM, 30 min) 在体内积累了迁移率较低的 ERO1α形式[1]。

[References]

[1]. Jaime D Blais, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃NO₄

[ Molecular Weight ]:
295.29

Related Compounds

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