Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt

Names

[ Name ]:
Acetyl-Calpastatin (184-210) (human) trifluoroacetate salt

Biological Activity

[Description]:

Acetyl-Calpastatin(184-210)(human) is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[In Vitro]

Acetyl-Calpastatin(184-210)(human) (peptide 1; 12.5-100 μM) inhibits calpains in LCLC 103H cells with an IC50 of 27 μM[1].

[References]

[1]. Ferdinando Fiorino, et al. A new cell-permeable calpain inhibitor. J Pept Sci. 2007 Jan;13(1):70-3.

[2]. Benjamin P Davis, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016 Apr;1(4):e86355.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄₂H₂₃₀N₃₆O₄₄S

[ Molecular Weight ]:
3177.63000

[ Exact Mass ]:
3175.66000

[ PSA ]:
1311.44000

[ LogP ]:
3.43000

[ Appearance of Characters ]:
powder

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 1 mg/mL

Safety Information

[ WGK Germany ]:
3

Related Compounds

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