DS-5272

Names

[ Name ]:
DS-5272

Biological Activity

[Description]:

A potent and orally active p53-MDM2 interaction inhibitor with IC50 of 2.4 nM; inhibits SJSA-1 cell proliferation with GI50 of 0.17 uM, demonstrates excellent antitumor efficacy on SJSA-1 xenografted models with high safety and good PK profiles.

[References]

References 1. Miyazaki M, et al. Bioorg Med Chem. 2015 May 15;23(10):2360-7. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₈Cl₂F₂N₆O₂S

[ Molecular Weight ]:
703.675

Related Compounds

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