DS-1040 tosylate hydrate

Names

[ Name ]:
DS-1040 tosylate hydrate

Biological Activity

[Description]:

DS-1040 tosylate hydrate (DS1040) is a small molecule inhibitor of the activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC50 of 1.7 ng/mL for rabbit TAFIa; a novel fibrinolysis-enhancing agent has favorable pharmacokinetic/pharmacodynamic properties and a favorable safety profile Stroke Phase 2 Clinical

[References]

References 1. Zhou J, et al. J Thromb Haemost. 2017 May;15(5):961-971. 2. Gurewich V, et al. J Thromb Haemost. 2017 Oct;15(10):2080-2081. 3. Paul A Lapchak, et al. Abstract WP282: DS-1040 an Inhibitor of the Activated Thrombin Activatable Fibrinolysis Inhibitor Improves Behavior in Embolized Rabbits, Stroke. 2016;47:AWP282. View Related Products by Target Other Targets Stroke

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₇N₃O₆S

[ Molecular Weight ]:
483.624

Related Compounds

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