EC-11716
Names
[ CAS No. ]:
1235486-15-3
[ Name ]:
EC-11716
Biological Activity
[Description]:
EC-11716 (EC/11716) is a novel mycobacterium tuberculosis gyrase inhibitor with potent anti-tubercular activity (MIC 0.38 uM, M. tuberculosis H37Rv).EC/11716 is active against M. abscessus subspecies and clinical isolates, maintains comparable activity against a panel of clinical isolates covering the M. abscessus complex.EC/11716 is effective against M. abscessus biofilms (MIC 0.78 uM), with better bactericidal activity against biofilms than moxifloxacin.EC/11716 is active against M. abscessus in vivo.
[References]
1. Uday S Ganapathy, et al. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0151421.
Chemical & Physical Properties
[ Molecular Formula ]:
C23H28ClN5O3
[ Molecular Weight ]:
457.959
Related Compounds
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