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hPGDS-IN-1

Names

[ CAS No. ]:
1234708-04-3

[ Name ]:
hPGDS-IN-1

[Synonym ]:
2-pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]benzylamide
SAR-191801
hPGDS-IN-1

Biological Activity

[Description]:

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.IC50 value: 12 nMTarget: hPGDSThe detailed information please refer to WO2011044307A1 and WO2010080563A2

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> PGE synthase
Research Areas >> Inflammation/Immunology

[References]

[1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

[2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.

[3]. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 19


[Related Small Molecules]

Sinensetin | Zomepirac (sodium salt) | Flurbiprofen | Limaprost | MF63 | Benzindamine Hydrochloride | Bismuth Subsalicylate | HPGDS inhibitor 1 | Pranoprofen | Suprofen | PGS-IN-1

Chemical & Physical Properties

[ Molecular Formula ]:
C22H20N6O3

[ Molecular Weight ]:
416.43300

[ Exact Mass ]:
416.16000

[ PSA ]:
126.92000

[ LogP ]:
3.13690

[ Storage condition ]:
2-8℃

Related Compounds