palmostalin B

Names

[ Name ]:
palmostalin B

[Synonym ]:
palm. B
palmostatin B
PALMOSTATIN B

Biological Activity

[Description]:

Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[References]

[1]. Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.

[2]. Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₆O₄

[ Molecular Weight ]:
376.53

[ Exact Mass ]:
376.26100

[ PSA ]:
44.76000

[ LogP ]:
5.70880

Related Compounds

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