1233365-12-2

1233365-12-2 structure

Name: palmostalin B
Chemical Name: palmostalin B
CAS Number: 1233365-12-2
Molecular Formula: C₂₃H₃₆O₄
Molecular Weight: 376.53
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2017-02-02 20:31:48
Modify Date: 2025-08-25 18:09:46
Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].

Name	palmostalin B
Synonyms	palm. B palmostatin B PALMOSTATIN B

Description	Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
References	[1]. Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306. [2]. Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56.