Phyltetralin

Names

[ Name ]:
Phyltetralin

[Synonym ]:
phyltetralin
(1R,2S,3S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-2,3-bis-methoxymethyl-1,2,3,4-tetrahydro-naphthalene
Phyltetralin

Biological Activity

[Description]:

Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

Research Areas >> Inflammation/Immunology

[In Vitro]

Phyltetralin shows inhibition on Polymorphonuclear neutrophil (PMN) chemotaxis with an IC50 of 4.01 µM[2]. Phyltetralin shows strong inhibition against reactive oxygen species (ROS) production from PMA-stimulated neutrophil with an IC50 of 0.73 µM[2]. Phyltetralin shows weak inhibition on CD18 expression and moderate inhibition on engulfment activity[2].

[References]

[1]. Conrado GG, et al. Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity. Planta Med. 2020 Jul;86(11):782-789.

[2]. Yuandani, et al. 1, 7, 8-trihydroxy 2-naphtaldehyde, ethyl 8-hydroxy-8-methyl-tridecanoate and 1-triacontanol from Phyllanthus amarus Schumach. & Thonn. inhibit phagocytic activity of human leucocytes[J]. Journal of Pharmacy and Pharmacology, 2019, 71(9): 1451-1457.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂O₆

[ Molecular Weight ]:
416.51

[ Exact Mass ]:
416.22000

[ PSA ]:
55.38000

[ LogP ]:
3.93420