123048-17-9

123048-17-9 structure

Name: Phyltetralin
Chemical Name: (+)-phyltetralin
CAS Number: 123048-17-9
Molecular Formula: C₂₄H₃₂O₆
Molecular Weight: 416.51
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK ROS
Create Date: 2018-09-13 18:31:24
Modify Date: 2024-01-10 11:36:09
Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].

Name	(+)-phyltetralin
Synonyms	phyltetralin (1R,2S,3S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-2,3-bis-methoxymethyl-1,2,3,4-tetrahydro-naphthalene Phyltetralin

Description	Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Inflammation/Immunology
In Vitro	Phyltetralin shows inhibition on Polymorphonuclear neutrophil (PMN) chemotaxis with an IC50 of 4.01 µM[2]. Phyltetralin shows strong inhibition against reactive oxygen species (ROS) production from PMA-stimulated neutrophil with an IC50 of 0.73 µM[2]. Phyltetralin shows weak inhibition on CD18 expression and moderate inhibition on engulfment activity[2].
References	[1]. Conrado GG, et al. Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity. Planta Med. 2020 Jul;86(11):782-789. [2]. Yuandani, et al. 1, 7, 8-trihydroxy 2-naphtaldehyde, ethyl 8-hydroxy-8-methyl-tridecanoate and 1-triacontanol from Phyllanthus amarus Schumach. & Thonn. inhibit phagocytic activity of human leucocytes[J]. Journal of Pharmacy and Pharmacology, 2019, 71(9): 1451-1457.