HA-155

Names

[ Name ]:
HA-155

[Synonym ]:
{4-[(4-{(Z)-[3-(4-Fluorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}phenoxy)methyl]phenyl}boronic acid
MFCD28016544
HA-155
Boronic acid, B-[4-[[4-[(Z)-[3-[(4-fluorophenyl)methyl]-2,4-dioxo-5-thiazolidinylidene]methyl]phenoxy]methyl]phenyl]-
HA-130

Biological Activity

[Description]:

(E/Z)-HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z)-HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

Autotaxin[1]

[References]

[1]. Joncour A, et al. Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors [published correction appears in J Med Chem. 2018 May 10;61(9):4270]. J Med Chem. 2017;60(17):7371-7392.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
691.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₁₉BFNO₅S

[ Molecular Weight ]:
463.29

[ Flash Point ]:
371.7±34.3 °C

[ Exact Mass ]:
463.106110

[ LogP ]:
5.25

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.683

Related Compounds

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