AZD2423

Names

[ Name ]:
AZD2423

Biological Activity

[Description]:

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CCR

Signaling Pathways >> Immunology/Inflammation >> CCR

Research Areas >> Neurological Disease

[Target]

CCR2

[In Vitro]

AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].

[References]

[1]. AZD2423.

[2]. John G. Cumming. CCR2 antagonists for the treatment of neuropathic pain: The discovery and development of AZD2423.

[3]. Kalliomäki J, et al. A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia. Pain. 2013 May;154(5):761-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₉ClFN₅O₂

[ Molecular Weight ]:
425.93

Related Compounds

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