C 21

Names

[ Name ]:
C 21

[Synonym ]:
N-Acetyl-L-serylglycyl-N5-(2-chloroethanimidoyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-lysyl-L-valin e
L-Valine, N-acetyl-L-serylglycyl-N5-(2-chloro-1-iminoethyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-ly 
syl-

Biological Activity

[Description]:

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

IC50: 1.8 μM (PRMT1); 8.8 μM (PRMT6)[1]

[References]

[1]. Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₉₀H₁₆₁ClN₃₆O₂₄

[ Molecular Weight ]:
2166.92

[ Exact Mass ]:
2165.217285

[ LogP ]:
-11.97

[ Index of Refraction ]:
1.653

Related Compounds

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