1229236-78-5

1229236-78-5 structure

Name: C 21
Chemical Name: C 21
CAS Number: 1229236-78-5
Molecular Formula: C₉₀H₁₆₁ClN₃₆O₂₄
Molecular Weight: 2166.92
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2021-05-04 09:05:21
Modify Date: 2025-08-27 17:30:45
C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].

Name	C 21
Synonyms	N-Acetyl-L-serylglycyl-N5-(2-chloroethanimidoyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-lysyl-L-valin e L-Valine, N-acetyl-L-serylglycyl-N5-(2-chloro-1-iminoethyl)-L-ornithylglycyl-L-lysylglycylglycyl-L-lysylglycyl-L-leucylglycyl-L-lysylglycylglycyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-arginyl-L-ly syl-

Description	C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC50 of 1.8 μM. C21 inhibits PRMT6 with an IC50 of 8.8 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	IC50: 1.8 μM (PRMT1); 8.8 μM (PRMT6)[1]
References	[1]. Obiamaka Obianyo, et al. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14;11(9):1219-23.