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GSK 9027

Names

[ CAS No. ]:
1229096-88-1

[ Name ]:
GSK 9027

Biological Activity

[Description]:

GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[Target]

GR[2]


[In Vitro]

GSK9027 demonstrates reduced 2×GRE reporter activation and is partial agonists[2].

[References]

[1]. Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10(1): e0116773.

[2]. Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012

Chemical & Physical Properties

[ Molecular Formula ]:
C27H19F4N3O2S

[ Molecular Weight ]:
525.51700

[ Exact Mass ]:
525.11300

[ PSA ]:
72.37000

[ LogP ]:
7.94610

Related Compounds