Tigecycline hydrate

Names

[ Name ]:
Tigecycline hydrate

[Synonym ]:
Tigecyclin
9-t-Butylglycylamido-minocycline hydrate
Tigecycline hydrate

Biological Activity

[Description]:

Tigecycline hydrate is a broad spectrum glycylcycline antibiotic. Tigecycline hydrate is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline hydrate is active against resistant strains of Gram-positive and Gram-negative bacteria.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Anti-infection >> Bacterial

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₉N₅O_8.xH₂O

[ Molecular Weight ]:
603.66400

[ Exact Mass ]:
603.29000

[ PSA ]:
219.47000

[ LogP ]:
2.48240

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H319-H360

[ Precautionary Statements ]:
P201-P305 + P351 + P338-P308 + P313

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QI7619500

Articles

Tigecycline inhibits proliferation of Acanthamoeba castellanii.

Parasitol. Res. 114(3) , 1189-95, (2015)

Acanthamoeba is an opportunistic protozoan parasite responsible for different diseases in humans, such as granulomatous amoebic encephalitis and amoebic keratitis. Tigecycline, a third-generation tetr...

Novel drug combination for Mycobacterium abscessus disease therapy identified in a Drosophila infection model.

J. Antimicrob. Chemother. 69(6) , 1599-607, (2014)

Mycobacterium abscessus is known to be the most drug-resistant Mycobacterium and accounts for ∼80% of pulmonary infections caused by rapidly growing mycobacteria. This study reports a new Drosophila m...

Pharmacokinetics of intravenously administered tigecycline in eye compartments: an experimental study.

Graefes Arch. Clin. Exp. Ophthalmol. 252(12) , 1993-7, (2014)

The purpose of this study was to evaluate the ocular distribution of intravenously administered tigecycline in a rabbit uveitis model.Tigecycline, which has a broad spectrum of activity against many g...

Related Compounds

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